The biannual CORE newsletter has the goal to keep you updated on all CORE related activities. If you have any news, ideas or comments to share feel free tocontact us!
Welcome to the first newsletter from the CORE Network
A large proportion of the current pharmaceuticals is chiral and this is expected to rise. In order to arrive at a highly pure chiral crystalline product and to avoid harmful side-effects of the counter enantiomer the pharmaceutical industry needs efficient, robust and reliable resolution & deracemization processes. The CORE Network is a four year Horizon2020 Marie Skłodowska-Curie Innovative Training Network on Continuous Resolution & Deracemization of Chiral Compounds by Crystallization funded by the EU. The CORE Network aims to construct a CORE Industrial Toolbox on Continuous Resolution that provides next generation tools, approaches and methods to industry for the development continuous resolution processes. While constructing the toolbox, the CORE Network trains 15 PhD students to give them the range of skills needed to succeed in future academic and industrial positions.
Since the network came into being 2 years ago the 15 PhD students worked hard on their Chiral Resolution research. In this newsletter you can find some information on the interesting scientific papers they published. You can read how the PhD students experience the CORE Network in the regularly appearing blogs on the CORE Network website. All network researchers participated in the BIWIC conference that took place in Rouen (France) last year, 5-7 September 2018. The participants of this conference had the chance to judge photos of chiral crystals from the high school crystal growth competition we organized as an outreach event.
We hope this newsletter gives you a good overview of the lively network and the exciting research taking place in it.
Joop ter Horst (CORE Network Coordinator), Elias Vlieg (CORE Network Dissemination Committee Chair)
For the full publication list, conference/workshop posters, book chapters or blog posts, see here.
Published papers can be obtained upon request from the project manager.
Next Event: CORE Workshop - Chirality in Practice TheCORE Workshop - Chirality in Practicewill take place on 20-24 May 2019 in Groningen, the Netherlands hosted by Beneficiary Partner, Syncom. All Early Stage Researchers (ESRs) and their supervisors, together with representatives of the associate partner organisations, external experts, and the project manager will meet to discuss the CORE project.
CORE Research Work Packages
WP3: Towards Continuous The main task of WP3 is to deliver rules of continuous resolution processes crystallization based. Preferential Crystallization and Viedma Ripening are the principal techniques on which the WP works. They allow forming homochiral crystals starting from a racemic mixture of the two enantiomers using a very small amount of seeds of the target enantiomer. While, so far, these processes have been developed and successfully applied in batch reactors, making continuous process configurations is challenging for a number of areas. The WP combines process modelling and experiments in a joint effort among ESRs 1 to 4.
WP4: Hybrid Resolution The work package 4 focuses on hybrid resolution processes combining racemization and crystallization. Since racemization is a real bottleneck for the Viedma ripening process, an important part of the WP4 aims to explore the applicability of several racemization routes such as photoracemization, high temperature-based racemization and acid-base racemization. Besides that, the optimization of the process steps and parameters covers another big area of interest. ESRs 5 to 9 work in a joint effort to try to find answers to the problems arising from these challenges.
WP5: Enabling Resolution The Work Package 5 bases its research on five tasks: i) development of an enhanced cocrystallization rules using networks to explore new MCS conglomerate possibilities; ii) development of a new device for detecting conglomerates using SHG-Analysis; iii) resolution of racemic systems through their stable/metastable conglomerate by means of preferential crystallization process; iv) development of PAT technique for online monitoring of the resolution process; v) automated sampling setup to validate the chiral application and utilization of developed devices in relevant industries. ESRs 10 to 15 are involved in this work package.
The final CORE Workshop will take place on 8-11 October 2019 in Erlangen, Germany hosted by Beneficiary Partner Friedrich - Alexander University Erlangen - Nürnberg, Germany (FAU). This event will finish with a mini open symposium - speakers will be announced shortly.
Summer School on Chiral Crystallization, Resolution & Deracemization hosted by Radboud University Nijmegen, The Netherlands, 3-6 July 2017.
Workshop on Solid State Properties hosted by Associate Partner TeraCrystal in Cluj, Romania, 6-10 November 2017.
Workshop and Mid-term Review hosted by University of Rouen, France, and Associate Partner PCAS, 3-5 September 2018.
Crystal Growth Competition
The Early Stage Researchers (ESRs) organized a European Crystal Growth Competition for high schools in the neighborhood of the ESR host institutions. High school students were being invited to the host institute for an explanation on crystallization and a lab tour. They were then provided with the materials and methods to grow crystals and make them large enough to use normal photography for a good impression. The crystal pictures were displayed on the CORE website and a winning artistic and scientific picture was chosen during the BIWIC conference, 6-7 September 2018. Further information and photographs from this competition can be found here.
The winning images
1st place winners, University of Rouen entry from Lycée Camille Saint-Saens by students Charlotte Bourdelles, Mélissa Chaouadi, Alice Dazy
2nd place winner, University of Strathclyde entry from Springburn Academy by student Bassim Sartawi
3rd place winner, Otto von Guericke University Magdeburg entry from Werner-von-Siemens-Gymnasium
During the CORE project, all the 15 ESRs will spend part of their research training in partner institutes. The final goal of each visit would be to come to a joint scientific paper on a well defined project. For all ESRs, visits/secondments are planned at the secondary supervisor institute, at an academic partner as well as at an industrial partner. In addition to their knowledge skills development, the secondments provide interdisciplinary training and intersectoral awareness will be facilitated. The duration of each secondment is planned together with the host supervisors.
There are currently no ongoing secondments.
Carola Tortora, Friedrich-Alexander-Universitat Erlangen, Germany.
Host: Merck KGaA - Central Process Development PM-OT / Cryst.Lab PM-OTS-D, Germany - June-September 2019.
Ryusei Oketani, University of Rouen, France.
Host: Merck KGaA - Central Process Development PM-OT / Cryst.Lab PM-OTS-D, Germany - April-May 2019.
Ghufran ur Rehman, University of Manchester, UK.
Host: Merck KGaA - Central Process Development PM-OT / Cryst.Lab PM-OTS-D, Germany - September-October 2019.
Johannes Hoffmann, University of Strathclyde, Scotland.
Host: SYNCOM, The Netherlands - April-May 2019.
Lina Harfouche, University of Rouen, France.
Host: Corbion Purac - Purac Biochem BV, The Netherlands - June-July 2019.
Raghunath Venkatramanan, University of Strathclyde, Scotland.
Host: Corbion Purac - Purac Biochem BV, The Netherlands - May 2019.
Brigitta Bodák, ETH Zurich (Swiss Federal Institute of Technology in Zurich), Switzerland.
Host: Process Systems Enterprise (PSE), UK - Summer 2019.
Aliou Mbodji, University of Rouen, France.
Host: TeraCrystal, Romania - June 2019.
Jan-Joris Devogelaer, Radboud University Nijmegen, The Netherlands.
Host: TeraCrystal, Romania - June 2019.
Giuseppe Belletti, Radboud University Nijmegen, The Netherlands.
Host: TeraCrystal, Romania - June 2019.
External Upcoming Events
1st. International Young Professionals Conference on Process Engineering (YCOPE 2019), 18-20 March 2019 at the Max Planck Institute for Dynamics of Complex Technical Systems (MPI) in Magdeburg, Germany - https://www.mpi-magdeburg.mpg.de/YCOPE2019