3CTN Supporting Trial Development in the Adolescent and Young Adult (AYA) Population
Adolescents and Young Adults (AYA) diagnosed with cancer have a unique set of challenges throughout their cancer journey and historically there have been limited formal clinical trials available to this population. To help support research in this important yet underserved segment of the Canadian cancer population, 3CTN is facilitating the development of a new clinical trial for the AYA population. The process began in the spring of 2015 with the release of a request for applications, which asked AYA researchers to submit clinical trial proposals.
Over the past few months, through a formal review and selection process, one project proposal for a trial in Acute Lymphoblastic Leukemia (ALL) was ultimately selected. On November 30 2015, 3CTN and our collaborators* held a workshop in Montreal, Quebec focused on developing this proposed pan-Canadian clinical trial. The workshop brought together principal investigators and site research staff from many Canadian pediatric and adult cancer centres with the common goal of launching a trial to address current knowledge gaps in AYA ALL therapy. Topics covered at the workshop included prioritizing the clinical needs of AYA ALL patients, identification of potential new agents and the status of the relevant diagnostic tests that will be required for a trial. A smaller working group will now focus on designing a draft protocol for a study to open within the next year. Clinical trials targeted to AYA with ALL will ultimately improve the standard of care and health outcomes for this population.
After the workshop, 3CTN provided a satisfaction survey and invited participants to provide feedback on the workshop. Nearly 70 per cent of attendees responded to the survey and indicated that overall, they were pleased with the workshop and that it met its stated goals and objectives.
The final goal of this AYA ALL trial development process will be a clinical trial in which Network centres can participate via the 3CTN Portfolio. Collectively our Network’s involvement may help decrease the knowledge gap in therapy for AYA Canadians diagnosed with ALL.
*The AYA Trial development workshop was sponsored in part by 3CTN and Jazz Pharmaceuticals (unrestricted educational grant). In addition, this workshop would not have been possible without the assistance of 3CTN, C17 and SickKids staff, in particular Donna Berry, Program Manager, Garron Family Cancer Centre.
AYA workshop attendees, November 10, 2015, Montreal, Quebec
Figure 1. Recruitment to Year 2 Network target by local regional node (Network Target = Baseline + 25 per cent). Progress has been calculated based on Year 2 recruitment reports from sites and year to date target. Note: Any regional node exceeding the green bar are on track to meet Year 2 annual Network recruitment target.
Patient and Public Involvement
Enhancements to the 3CTN PPI Website!
3CTN launched the 3CTN Guide to Patient and Public Involvement as a part of the 2015 Annual Stakeholder meeting. While this Guide represents one major pillar of the 3CTN PPI program, it is best viewed as a ‘jumping off point’ when Network site staff and Lay Representatives want to learn about PPI within the 3CTN framework. 3CTN tools and information are found on the “Patient/Public” tab on the main 3CTN webpage.
The PPI website enhancements augment the PPI Guide by providing more education and tools for 3CTN stakeholders interested in 3CTN PPI activities. The main changes to the website are described below:
“Live” PPI Toolkits:
The addition of two PPI Toolkits will be very helpful for 3CTN site staff and Lay Representatives. On the main PPI page there are separate toolkits for “Network Sites” and “Lay Representatives”, with user specific information and tools. In the Lay Representative toolkit, one feature new 3CTN Lay Representatives may find useful is the ‘Helpful Links’ section, which lists clinical trial training and information websites. More 3CTN PPI tools will be added to their respective toolkit in the coming months.
The PPI News page is yet another development on the 3CTN PPI website. This page will highlight exciting activities and advancements within the PPI program. All 3CTN stakeholders are encouraged to submit stories ideas or other PPI-related announcements to the 3CTN Coordinating Centre to be posted on this page.
The 3CTN Coordinating Centre and the Lay Representative Advisory Council are excited about what the PPI website enhancements can offer to Network sites and Lay Representatives to support PPI activities across the Network. If you have feedback or suggestions for website improvements, feel free to contact us email@example.com