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Worldwide Twins
International Network of Twin Registries

Newsletter - Issue 5
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The year is almost over...

It has been a very fruitful year for the International Network of Twin Registries. The meeting in Osaka has been followed by a number of new ideas and initiatives. On this current issue, we will introduce a "Profile" section so we can promote available resources for global global collaboration in twin research. Please get in touch with us at info@worldwidetwins.net if you want to profile your registry, cohort, study or similar resource. We wish you all a nice Christmas and a successful 2016! 

Profile - Older Australian Twins Study (OATS)

The Older Australian Twins Study (OATS) aims to examine genetic and environmental factors for cognitive decline and dementia in late life. We are a multi-centre, longitudinal study incorporating identical and non-identical twin pairs aged 65 years and older. Baseline, two-year and four-year follow-up data have been collected on a wide range of parameters. Participants have undergone rigorous medical and cognitive function tests, provide blood samples and have a MRI scan of their brain. Information about environmental factors, such as medical and psychosocial history, lifetime physical and mental activity, falls and cardiovascular history, and nutrition has also been collected. Data from the study has made significant contributions to understanding the genetic versus environmental factors underlying aspects of cognition, brain structure, and the role of proteins in healthy ageing. MRI and blood data has contributed to understanding the heritability of brain structure and function, the role of brain metabolites, and the epigenetics of memory and learning. Current work is utilising the longitudinal data to progress research in these fields. We are continually seeking novel opportunities for collaboration to further research into healthy ageing. If you would like further information please contact, Jocelyn Bowden, OATS Study Coordinator on jocelyn.bowden@unsw.edu.au, or visit our website at cheba.unsw.edu.au/project/older-australian-twins-study.

New ideas for collaboration

Jeff Craig (Australian Twin Registry) would like to send out a request for registries that have information about three neuro developmental disorders: autism, cerebral palsy and epilepsy. Availability of data (and samples) from discordant pairs will be highly appreciated. The idea is to replicate current and future data from methylation and other 'omic' platforms. If you can help, please email Jeff at jeff.craig@mcri.edu.au.


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