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Newsletter #117
November 9th, 2017
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Dear Friends,

We begin this November newsletter with an article summarizing two recent humanized mouse studies that support the link between the gut microbiome and the autoimmune disease multiple sclerosis.

Next comes a pair of studies on gut microbiota that are big news in the field: (1) a large clinical trial in India showing newborns given a probiotic + prebiotic (that is, a synbiotic) had a significantly lower risk of sepsis; and (2) a new analysis of samples from the Human Microbiome Project, providing an updated body-wide metagenomics profile of the human microbiome.

The final two articles in this newsletter relate to mechanism. The first describes a mouse study showing how a particular gut microbe mediates the immune response to influenza infection through the breakdown of flavonoids. The second shows how histamine, a metabolite produced by Lactobacillus reuteri, reduces inflammation and suppresses colonic tumors in mice.

The GMFH publishing team

Two new studies support the link between the gut microbiome and multiple sclerosis

A large clinical trial in India finds a synbiotic may help prevent neonatal sepsis

Sepsis is a life-threatening condition characterized by systemic inflammation; it is one of the major contributors to neonatal mortality, especially in developing countries. The World Health Organization (WHO) estimates that 1 million deaths per year...

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The Human Microbiome Project has provided an updated metagenomic profile of the human microbiome

Both the Metagenomics of the Human Intestinal Tract (MetaHIT) project, supported by the European Comission under the 7th Framework program, and the Human Microbiome Project (HMP), supported by the National Institutes of Health (NIH), are...

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A microbial metabolite mediates protection against influenza infection through type I interferon signalling in mice

Previous preclinical research has shown that the gut microbiota helps modulate the host response to influenza infection -germ-free or antibiotic-treated mice usually exhibit weak protection against influenza virus. However, underlying mechanisms mediating this...

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Lactobacillus reuteri suppresses inflammation-associated colon carcinogenesis in mice by histamine production

Previous research has shown that the human gut microbiota may mediate suppression of carcinogenesis through its interaction with host immunity. Among cancer types, colorectal cancer (CRC) is the third most common cancer and the third...

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