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Newsletter #149
April 25th, 2019


Dear Friends,

We begin this edition of our newsletter with a new mice study that shows how changes related to aging in the gut microbiome mediate arterial dysfunction, while oxidative stress and inflammation are both normalized.

Next up, we cover a new cross-sectional study, which has found that interactions between the gut microbiota and bile acid metabolism may partially mediate the success of bariatric surgery in the medium term. You will also find a new study showing the adaptive behavior of the Escherichia coli Nissle probiotic in the mouse gut, opening new avenues for moving towards personalized probiotic medicine.

Finally, we have two new studies on the potential role of gut microbial signatures for predicting colorectal cancer (CRC), validated using whole-metagenome shotgun datasets across CRC cohorts from different countries.

Happy reading!

The GMFH publishing team

Gut microbiome changes emerge as a potential modulator of age-associated cardiovascular disease risk

Bariatric surgery success may rely on gut microbiota composition


Bariatric surgery (BS) appears as a solution for managing cardiovascular risk in people with a severe and morbid Body Mass Index (BMI > 35-40 kg/m2). Although previous research has shown that...

The gut microbiome, diet and antibiotic treatment all shape E. coli Nissle evolution in the mouse gut


Probiotics have different potential therapeutic uses, although their mechanisms of action and how they might change after administration are not fully studied. In contrast to traditional drugs, probiotics...

Two new studies reveal universal gut microbiome signatures in colorectal cancer


Genes alone cannot explain the current rise in colorectal cancer (CRC) and scientists are now trying to elucidate the gut microbiota’s contribution as an important player. Previous human research has shown...

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