One of the many rewarding aspects working at GPI is knowing the impact our research scientists have all over the world. These two publications were a collaborated effort from one our post-docs, Dr. Paula Rodrigues-Miguelez. Her efforts reach as far as Spain and Sweden.
Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects
Yubisay Mejías-Peña, Brisamar Estébanez, Paula Rodriguez-Miguelez, Rodrigo Fernandez-Gonzalo, Mar Almar, José A. de Paz, Javier González-Gallego, María J. Cuevas
Objective: Aging is associated with a decline in autophagy and a state of low-grade inflammation which further affects apoptosis and autophagy. Importantly, these alterations could reverse with regular physical activity. This study assessed the effects of a resistance exercise training program on autophagy, NLRP3 inflammasome, and apoptosis in peripheral blood mononuclear cells (PBMCs) from elderly subjects. Results: The results obtained seem to indicate that 8-week resistance training stimulates autophagy, prevents NLRP3 inflammasome activation, and reduces apoptosis in PBMCs from elderly subjects. This data could have a significant impact in prevention and rehabilitation programs currently employed in the elderly population.