New calls for collaboration
Send us an email if you want your proposal reported in our next issue.
The Menarcheal Age and Gene-environment Impacts (MAGI) Study: an INTR Collaboration
Seung-Ah Choe (CHA Medical School, South Korea) and Joohon Sung (Seoul National University, South Korea) would like to invite new collaborators to their twin study named Menarcheal Age and Gene-environment Impacts (MAGI). The aims of this study are 1) to understand how the age at menarche (AAM) is changing over time and across the different populations, and 2) to identify the determinants of this change with particular emphasis on genetic and environmental factors. 3) to estimate and predict health consequences related with the global changes in AAM.
The study involves so far the participation of the Healthy Twin Study (South Korea), Australian Twin Registry (Australia), California Twin Program (USA) and Hungarian Twin Registry (Hungary). If you have relevant twin data regarding age at menarche to share for this study or want to know more, please contact Seung-Ah Choe by email.
Mendelian randomization and trait variability analyses using twins
George Davey Smith (University of Bristol, UK) and colleagues are recruiting samples for a collaborative effort with the following aims: 1) Estimating the causal relationship between phenotypes using DZ twins or siblings. Method: A within-family Mendelian randomization design that is immune to confounding by demography. 2) Identify genetic loci that influence phenotypic variability. Method: A GWAS meta-analysis on the phenotypic difference between MZ twins.
Data requirements: Genome-wide SNP data on MZ or DZ twins (only one MZ per pair is necessary) and any of the following phenotypes: body mass index, blood pressure and/or diagnosed hypertension as a categorical variable, height, IQ. Statistical power is a key limitation to both analyses so we are looking to recruit as many cohorts as possible to participate in these meta-analyses. Please fill in this form to join the collaboration, or contact George Davey Smith by email for further information.