New calls for collaboration
Send us an email if you want your proposal reported in our next issue.
Epigenetics Working Group
Shuai Li (University of Melbourne), John Hopper and Jeff Craig (Australian Twin Registry), and Richard Saffery (Murdoch Childrens Research Institute) would like to initiate an INTR Working Group for twin studies of epigenetics. The Working Group would aim to provide a platform for international collaborations on epigenetic research that utilise twin resources. An example of such collaboration is the project Shuai is leading on genetic and environmental determinants of variation in a measure of global DNA methylation using multiple twin and family studies conducted across the lifespan, which will be presented at the ICTS 2016 in Brisbane, Australia. If you have an interest or have twin data on epigenetics, please contact Shuai at firstname.lastname@example.org.
The Genetic Landscape of Twinning: First genes for dizygotic twinning reported from the Twinning GWAS Consortium (TGC)
Dorret Boomsma and colleagues established the TGC to characterize the genetic basis of DZ twinning in humans. Knowledge of these genes may identify key mechanisms controlling ovarian function and can provide a greater understanding of female fertility and infertility, the most common reproductive disorder. The first paper entitled “Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility” was published in the American Journal of Human genetics. Mbarek and colleagues performed a genome-wide association study (GWAS) for DZ twinning utilizing data from 1,980 mothers of DZ twins (MODZT) and 12,953 control subjects from three twins registries: Netherlands Twin Register, QIMR Berghofer Medical Research Institute and Minnesota Center for Twin and Family Research. Two genes (FSHB and SMAD3) were associated with having dizygotic twins and also linked to many aspects of female fertlity. The results were validated in a large Icelandic cohort. This is the first meta-analysis for GWAS of mothers of DZ to reveal the genetic factors contributing to twinning.
We are looking for cohorts with genotyped data of mothers of DZ twins to join our consortium and contribute to the discovery of more genes associated with twinning. If you would like further information please contact Hamdi Mbarek email@example.com or Dorret Boomsma firstname.lastname@example.org